[HTML][HTML] Muscle and adipose tissue insulin resistance: malady without mechanism?

DJ Fazakerley, JR Krycer, AL Kearney… - Journal of Lipid …, 2019 - ASBMB
… of impaired glucose tolerance and impaired fasting glucose. … Insulin action and resistance
in obesity and type 2 diabetes. … (TAG) stores in adipose tissue (lipolysis) provide substrates for …

100th anniversary of the discovery of insulin perspective: insulin and adipose tissue fatty acid metabolism

AC Carpentier - American Journal of Physiology …, 2021 - journals.physiology.org
insulin-mediated suppression of adipose tissue lipolysis is the … hepatic, not skeletal muscle
or adipose tissue insulin sensitivity … post-oral glucose tolerance test (OGTT) plasma glycerol …

Insulin resistance in type 2 diabetes

M Roden, KF Petersen, GI Shulman - Textbook of diabetes, 2024 - Wiley Online Library
… of glucose tolerance preceding type 2 diabetes comes from … concentrations [47] in skeletal
muscle of type 2 diabetes … within adipose tissue, inhibit insulin- mediated lipolysis in white …

Is insulin resistance tissue-dependent and substrate-specific? The role of white adipose tissue and skeletal muscle

D Calderón-DuPont, I Torre-Villalvazo… - Biochimie, 2023 - Elsevier
… Although obesity is the result of adipose tissue expansion, it is … in adipose tissue impairs
whole body glucose tolerance [26]. … of glycerol by lipolysis is not recaptured by adipose tissue, …

Insulin: The master regulator of glucose metabolism

L Norton, C Shannon, A Gastaldelli, RA DeFronzo - Metabolism, 2022 - Elsevier
… protein, skeletal muscle function is heavily reliant on the insulin-mediated uptake of glucose
and … through primary effects on adipose tissue lipolysis and free fatty acid (FFA) availability. …

[HTML][HTML] Black African men with early type 2 diabetes have similar muscle, liver and adipose tissue insulin sensitivity to white European men despite lower visceral fat

O Bello, C Mohandas, F Shojee-Moradie, N Jackson… - Diabetologia, 2019 - Springer
… body, skeletal muscle, hepatic or adipose tissue insulin sensitivity … Insulin-mediated peripheral
glucose uptake (a), suppression … [39], suggesting that by the end of the glucose tolerance

Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans

S Sachs, S Zarini, DE Kahn… - American Journal …, 2019 - journals.physiology.org
glucose tolerance test to verify glucose tolerance. Percent … controls have less inhibition
of muscle and IMAT lipolysis in … in overweight and obese patients with type 2 diabetes. …

Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver

GH Goossens, JWE Jocken, EE Blaak - Nature Reviews Endocrinology, 2021 - nature.com
… in adipose tissue distribution, adipose tissue, skeletal muscle … mass than men of the same
age and BMI. Premenopausal … fatty acid isotope tracer), reflecting adipose tissue lipolysis, …

The integrative biology of type 2 diabetes

M Roden, GI Shulman - Nature, 2019 - nature.com
… The critical importance of skeletal muscle is illustrated by the … adipose tissue than in plasma,
and increased adipose tissue … EGP, impaired insulin-mediated suppression of lipolysis, EGP …

[HTML][HTML] Diabetes mellitus and its metabolic complications: the role of adipose tissues

L Dilworth, A Facey, F Omoruyi - International journal of molecular …, 2021 - mdpi.com
… utilize insulin for insulin-mediated glucose transport into tissues, … resistance in the liver, fat,
and skeletal muscle tissue [21]. … , regulation of fat storage and energy, glucose tolerance, and …